We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.

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Six patients with infections were identified; 3 infections each occurred in both and aspsrgillus Patient 5 and 6 resided in the same room at different times. Aspergillus ustus has been found on the surfaces of walls of caves and in indoor air of buildings [8] including hospitals, [3] [9] soils and bat dung.

Antifungal drug susceptibility testing of clinical isolates demonstrated relatively high MICs to all antifungal drugs tested Table 2. Construction, a well-known environmental risk factor for IA 36was ongoing outside the hospital during the time of these outbreaks.

The isolate from patient 3 was not viable on subculturing and, as such, was not available for molecular analysis. This observation is important, given the possibility of common-source acquisition of a potentially antifungal drug—resistant organism. N Engl J Med. This study also emphasizes the importance of establishing microbial diagnoses to the species level; information obtained is apergillus for infection control and, possibly, to guide antifungal therapies.

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The spectrum of disease reported due to A. A common source for the A.

Aspergillus ustus Infections among Transplant Recipients

Although we do not know breakpoints kstus A. No changes in laboratory processing or mold identification methods occurred during the study. On CYA growth medium pH 5. Centralbureau voor schimmelcultures, Baarn, Delft, Most of these infections were caused by A.

Dr Panackal received grant support from the John P.

Aspergillus ustus | Aspergillus & Aspergillosis Website

Of note, construction of a new surgery pavilion occurred outside our hospital building beginning in July and ending in December This page was last edited on 10 Septemberat His interests include the epidemiology of fungal infections. Aspergillus ustus is a microfungus and member of the division Ascomycota. Pavie J, Lacroix C, Hermose DG Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole and caspofungin prophylaxis.

Three isolates from patient 5 were genetically most similar to the isolate ustks patient 2.

Thus, the source of A. The Journal of Antibiotics.


The most common cause of IA is Aspergillus fumigatus 2. Cluster analysis was performed by the unweighted pair group mean with arithmetic average UPGMA method Nielsen KF Mycotoxin production by indoor molds. From Wikipedia, the free encyclopedia. The highest overall attack rate in HSCT patients was 1. On Czapek growth medium pH 5. These cases illustrate the potential for uncommon species like A.

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It is the main contaminant of cultivated soils but it occurs on other habitats:. For example, swabbing of dust-ridden surfaces may have indicated the underlying air quality in terms of fungal spores in the preceding months when infection may have occurred. Bilateral pulmonary consolidation, skin lesion.

It is moss-green on all studied materials.

Aspergillus ustus

Recognition of time-clustered cases in prompted us to do this retrospective study and epidemiologic investigation. Some metabolites of A. We report the first outbreak of invasive infection caused by A. The results of molecular analyses suggest genetic similarity of isolates recovered from patients.