BARTOCCIONI 2012 PDF
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Maintenance of serum antibody levels. Annals of the Rheumatic Diseases. Abstract Background Serological levels of free immunoglobulin light chains FLCsproduced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab RTX therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus.
European Journal of Neurology. Its treatment can be unrewarding, owing to poor response to acetylcholinesterase inhibitors in most patients, disease relapses in spite of high-dose immunosuppression, bratoccioni development of brtoccioni bulbar weakness.
Free bartoccinoi chains of immunoglobulins in serum from patients with rheumatoid arthritis, sarcoidosis, chronic infections and pulmonary cancer. Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc.
Elevation of serum immunoglobulin free light chains during the preclinical period of rheumatoid arthritis. Hum Mutat, 35 4 T-type amino acid transporter TAT1 Slc16a10 is essential for extracellular aromatic amino acid homeostasis control.
Current Topics in Microbiology and Immunology.
Published online Mar Varese 15 Aprile Tulburari alimentare. Author information Article notes Copyright and License information Disclaimer. Find all citations in this journal default. Further elucidating these characteristics could lead to a better understanding of their 22012 roles in autoimmune disease development.
In serum, these excess polyclonal FLCs have a short bartoxcioni 2—6 hoursand barttoccioni are excreted by the kidney [ 3 ]. The Journal of Immunology. The statistical analysis revealed significant differences between patients and HBD: In the last few years, elevated concentrations of polyclonal FLCs in the serum and urine have been reported in patients with rheumatoid arthritis RAsystemic sclerosis SSprimary Sjogren syndrome pSSand systemic lupus erythematosus SLE [ 8 — 11 ].
Biol Chem, Journal of Clinical Investigation. Trends in Pharmacological Sciences.
P Natl Acad Sci Usa, 8 How does Europe PMC derive its citations network? It is confirmed by the combination of typical symptoms and signs, electromyographic and pharmacological tests, as well as by the detection of specific auto-abs. Also, changes of T and B cell subsets were evaluated as possible biomarkers of disease activity and eventually as therapeutic targets [ 21 ].
Several reports, analysing T and B cell subsets in MG patients, showed a disequilibrium between follicular and regulatory T cells together with a lower frequency of regulatory B cells.
Paola Chiara Bartoccioni | IRB Barcelona
Serological levels of free immunoglobulin light chains FLCsproduced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab RTX therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus.
CitePeer Related Articles http: Auto-abs bind to well-defined antigens in the postsynaptic membrane at the neuromuscular junction and impair nerve-muscle transmission, which in turn induces muscle weakness and excessive fatigability. Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice.
Epidemiological and immunological profile of muscle-specific kinase myasthenia gravis in Greece. Different groups had tried to identify such markers: Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients
Roles of plasmablasts and B cells in IgG4-related disease: First, due to the small sample size, only a few potential confounders could be controlled, mainly bartoccionl variables known to influence FLC levels, like kidney failure and plasmapheresis. Free immunoglobulin light chains: Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype.
A 5-year follow-up of rituximab treatment in patients with neuromyelitis optica spectrum disorder. None of them underwent plasmapheresis, brtoccioni received high dose intravenous immunoglobulins, during this study.
High-dose prednisone plus plasma exchange is the recommended approach for treating rapidly progressive bulbar weakness. Serum cytokine and chemokine profiles in patients with myasthenia gravis. The relationship between high-sensitivity CRP and polyclonal free light chains as markers of inflammation in chronic disease.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Gene Ontology GO Terms.
Even if it remained above vartoccioni cut-off of positivity, also specific anti-MuSK auto-abs titer decreased from 212. A truly useful biomarker should meet strict criteria: J Biol Chem, 43 Disease management can be difficult: Click here for additional data file.